Selected Publications 2025
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Cai Y, Guan Z, Tong Y, Zhao W, Zhang J, Peng L, Ip PPC, To SKY, Wong AST. Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis. Protein Cell. 2025 Jul 19;16(7):602-608. doi: https://doi.org/10.1093/procel/pwaf019. PMID: 40205990; PMCID: PMC12275092.
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Capps B, Chadwick R, Joly Y, Lajaunie C, Hauptmannova I, Mackenzie S, Mulvihill JJ, Mumford E, Rasmussen SA, Sanghavi K, Thaldar DW, Yeates J, Quinzin MC, Lederman Z. The Ecological Genome Project and the Promises of Ecogenomics for Society: Realising a Shared Vision as One Health. Bioethics. 2025 Nov;39(9):788-795. doi: https://doi.org/10.1111/bioe.70020. Epub 2025 Jul 24. PMID: 40704526; PMCID: PMC12511917.
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Cheng Ho, So J, Lam R, Ng H. External validation of the Haemorrhage Estimate Risk in Oral anticoagulation for Mild head trauma nomogram in Hong Kong. Hong Kong Journal of Emergency Medicine. 2025 Apr;32. doi: https://doi.org/10.1002/hkj2.12074.
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Chow TK, Lam RPK, Chan CK, Tse ML, Feng Y, Rainer TH. Acute Sophora alkaloid poisoning in Hong Kong. Toxicon. 2025 Feb;255:108251. doi: https://doi.org/10.1016/j.toxicon.2025.108251. Epub 2025 Jan 15. PMID: 39824462.
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Hou T, Ho MH, Lederman Z, Cheung DST, Rainer TH, Lin CC. Associations of social isolation and loneliness with healthcare utilization among older adults: a systematic review and meta-analysis. Innov Aging. 2025 Dec 10;10(1):igaf136. doi: https://doi.org/10.1093/geroni/igaf136. PMID: 41573673; PMCID: PMC12822840.
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Hui J, Zhou J, Lee Y, Chou O, Hou I, Leung K, Lee T, Li X, Liu T, Wai A, Cheung B, Tse G, Zhang Q. Effects of an Angiotensin converting enzyme inhibitors versus angiotensin II receptor blockers for pneumonia, influenza and lung related mortality risks: a retrospective population-based cohort study. Journal of the Hong Kong College of Cardiology. 2025 Aug;32(3). doi: http://dx.doi.org/10.55503/2790-6744.1555
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Jiao Y, Cai Y, Zhang Y, Choy KT, Cheng KM, Nicholls JM, Lam PK, Yen HL, Rainer TH. Use of H1N1 strain A/PR/8/34 influenza to build a mouse model of viral respiratory sepsis. Lab Anim Res. 2025 Jun 4;41(1):16. doi: https://doi.org/10.1186/s42826-025-00248-4. PMID: 40468456
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Kjær J, Milling L, Brøchner AC, Lippert F, Blomberg SN, Christensen HC, Holgate R, Morrison LJ, Bakhsh A, Mikkelsen S.... Lam RPK, Cheung ACK; Global Prehospital Resuscitation Network. Prehospital cardiac arrest resuscitation practices differ around the globe. Resusc Plus. 2025 Jun 24;25:101017. doi: https://doi.org/10.1016/j.resplu.2025.101017. PMID: 40777886; PMCID: PMC12329125.
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Lam RPK, Chua KK, Ku PY, Ting SC, Chow TK, Chan CK, Tse ML, Lau EHY, Rainer TH. Derivation and internal validation of a clinical diagnostic score for acute Chinese medicine poisoning involving aconite. Clin Toxicol (Phila). 2025 Jun 18:1-12. doi: https://doi.org/10.1080/15563650.2025.2512818. Epub ahead of print. PMID: 40528738.
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Lam RPK, Chan CK, Tse ML, Lau EHY, Tsui MSH, Chan SKW, Rainer TH. Factors associated with 30-day drug-related emergency department re-attendance among methamphetamine users: a territory-wide retrospective study in Hong Kong. BMC Emerg Med. 2025 Aug 22;25(1):166. doi: https://doi.org/10.1186/s12873-025-01325-6. PMID: 40847277; PMCID: PMC12374304.
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Lederman Z. Bioethics Needs Just War Theory, Not The Other Way Around. Am J Bioeth. 2025 May;25(5):121-123. doi: https://doi.org/10.1080/15265161.2025.2489623. Epub 2025 May 8. PMID: 40339091.
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Lederman Z. The boycott of the Israeli Medical Association by the British Medical Association: a critical appraisal. J Med Ethics. 2025 Nov 19:jme-2025-111499. doi: https://doi.org/10.1136/jme-2025-111499. Epub ahead of print. PMID: 41260914.
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Lederman Z. International Humanitarian Law and the Immunity of Hospitals in Gaza. Bioethics. 2026 Jan;40(1):12-20. doi: https://doi.org/10.1111/bioe.13433. Epub 2025 Jun 15. PMID: 40517410; PMCID: PMC12710681.
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Lederman Z, Irfan A, Lederman S. Is it genocide? yes it is—a response to Paul James. Journal of Bioethical Inquiry. 2025 Jun;22(2):471–4. doi: https://doi.org/10.1007/s11673-025-10467-y
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Lederman Z, Davidovitch N, Lederman S; Medical Ethics at War: Is Israel Obligated to Treat Hamas Combatants? Journal of Jewish Ethics. 2023 July;9(2):184–208. doi: https://doi.org/10.5325/jjewiethi.9.2.0184
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Lederman Z. One Health Economics 2.0 - commentary. Glob Bioeth. 2025 May 28;36(1):2511517. doi: https://doi.org/10.1080/11287462.2025.2511517. PMID: 40443691; PMCID: PMC12120855.
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Lederman, Z. Justice Before Pluriversality—A Response to Jecker et al. Journal of Bioethical Inquiry. 2025;22:457-462. doi: https://doi.org/10.1007/s11673-025-10444-5
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Lederman Z, Cheung EHEHL, Fong Lau JY, Leung G. Resuscitation-induced consciousness: clinical, philosophical, ethical, and legal aspects. Resusc Plus. 2025 Sep 29;26:101117. doi: https://doi.org/10.1016/j.resplu.2025.101117. PMID: 41142208; PMCID: PMC12547703.
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Lederman Z, Lai Ivan LH, Liu CN, Hames A, Menikoff J. Unit 731 and history-informed professional identity formation. Lancet. 2025 Feb 8;405(10477):465. doi: https://doi.org/10.1016/S0140-6736(24)02682-5. PMID: 39922669.
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Lee T, Lyu A, Jiang T, Chan S, Chan C, Yip E, Luk L, Ho J, So K, Tsui O, Lam M, Lee S, Yamamoto T, Tong C, Wong M, Wong E, Wai A, Rainer T. Effectiveness of Antivirals Nirmatrelvir-Ritonavir and Molnupiravir in Viral Sepsis: Retrospective Cohort Study. JMIR Public Health Surveill. 2025;11:e72124. doi: https://doi.org/10.2196/72124
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Lee TTL, Ju C, Chan SCL, Chou OHI, Chan JSK, Lee S, Liu T, Cheng SH, Zhang Y, Cheung BMY, Wai AK, Wei L, Tse G. Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients With Infective Endocarditis: A Target Trial Emulation. J Am Heart Assoc. 2025 Aug 5;14(15):e041965. doi: https://doi.org/10.1161/JAHA.125.041965. Epub 2025 Jul 17. PMID: 40673512; PMCID: PMC12449976.
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Leong W, Li C, Long Y, Wang Y, Wai AK, Huang Y, Lau F. Non-fatal acute barium carbonate poisoning following suicidal ingestion: A case report. SAGE Open Med Case Rep. 2025 Jan 4;13:2050313X241311316. doi: https://doi.org/10.1177/2050313X241311316. PMID: 39758194; PMCID: PMC11700400.
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Leung LHL, Kwok AY, Wong EK, Cheung ACK, Rainer TH. The Hong Kong emergency medical services system: A scoping review. Hong Kong Journal of Emergency Medicine. 2025 Jul;32(4):e70025. http://dx.doi.org/10.1002/hkj2.70025
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Li Q, Zhang X, Zhang Y, Lam RPK, Jin Y, Ji C, Fan W, Rainer TH. Metabolomic biomarkers could be molecular clocks in timing stroke onset. Sci Rep. 2025 Jul 1;15(1):21645. doi: https://doi.org/10.1038/s41598-025-05334-0. PMID: 40596000; PMCID: PMC12217631
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Li Q, Zhang X, Zhang Y, Lam RPK, Fan W, Jin Y, Ji C, Johnson JW, Rainer TH. Using proteomic biomarkers to estimate acute ischaemic stroke onset time. Commun Med (Lond). 2025 May 17;5(1):183. doi: https://doi.org/10.1038/s43856-025-00895-7. PMID: 40382445; PMCID: PMC12085557.
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Liang STH, Lam RPK, Chan NTJ, Leung MMK, Tsui SH, Rainer TH. Subclinical adrenal suppression and urine immunoassay detection of etomidate in an electronic cigarette user. Clin Toxicol (Phila). 2025 Mar 17:1-2. doi: https://doi.org/10.1080/15563650.2025.2476016. Epub ahead of print. PMID: 40094346
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Lu CCZ, Lederman Z. Response Paper: A Critical Review of Sprengholz's Public Preferences Regarding Slow Codes in Critical Care. Bioethics. 2026 Jan 4. doi: https://doi.org/10.1111/bioe.70073. Epub ahead of print. PMID: 41485237.
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Luk LYF, Ching CJY, Yip TF, Chan SCL, Lam CYT, Lam ETC, Yue SRB, Pang HC, Wong JYH, Wong CKH, Tong CK, Yamamoto T, Rainer TH, Wai AKC, Ho JWK. Incidence of Deliberate Self-Harm in Hong Kong Before and During the COVID-19 Pandemic: Population-Wide Retrospective Cohort Study. JMIR Public Health Surveill. 2025 Feb 10;11:e57500. doi: https://doi.org/10.2196/57500. PMID: 39930482; PMCID: PMC11832357.
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Mao H, Liu L, Lin P, Meng X, Rainer TH, Wu Q. Quantitative Electroencephalogram Might Improve the Predictive Value of Prognosis 6 Months After Discharge in Acute Ischemic Stroke. Clin EEG Neurosci. 2025 Mar 3:15500594251323119. doi: https://doi.org/10.1177/15500594251323119. Epub ahead of print. PMID: 40033800
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Rainer TH, Lam RPK, Tsang TC, Wai AK, Leung SC, Leung RYY, Wong CKH, Gill H, Lam WWT, Wing Lok Chan W, Chi Kin Cheung A, Lau MT, Lee SF, Choi YF, Fong Lun Lee H, Mok KL, Lam HC, Lee SY, Ho Ting Yeung M, Hung IF. Antibiotic stewardship in suspected neutropenic fever (ASTERIC trial): a multicentre, type 1 hybrid effectiveness-implementation, stepped-wedge, randomised controlled trial study protocol. BMJ Open. 2025 Nov 24;15(11):e108010. doi: https://doi.org/10.1136/bmjopen-2025-108010. PMID: 41290295; PMCID: PMC12645604.
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Razai MS, Bans M, Ozekmekci M I, Dabbagh H, Lederman Z. The healthcare community has a responsibility to highlight the ongoing destruction in Gaza. BMJ. 2025;389:r741. doi: https://doi.org/10.1136/bmj.r741
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So HY, Wong SSC, Wai AKC, Chan AKM, Cheng BCP. The complementarity of quantitative and qualitative methods: evaluating educational activities using mixed methods. Hong Kong Med J. 2025 Dec;31(6):416-418. doi: https://doi.org/10.12809/hkmj245176. Epub 2025 Dec 10. PMID: 41365805.
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So HY, Chan AKM, Wai AKC, Lam CKM, Lui CT, Choi YF, Chan PT, Chan LCN, Cheng BCP, Tham CCY, Li PKT. Establishing the Jockey Club Institute for Medical Education and Development (JCIMED): advancing postgraduate medical education in Hong Kong. Hong Kong Med J. 2025 Dec;31(6):419-421. doi: https://doi.org/10.12809/hkmj2512541. Epub 2025 Dec 5. PMID: 41345076.
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Spitale G, Germani F, Earp BD, Mann SP, Barış M, Annoni M, Aramesh K, Lederman Z, Ho CWL, Caals K, D'Imperio A, Ienca M, Singh S, Spagnolo D, Biller-Andorno N. On Religious Influence in Bioethics: The Limits of Pluriversalism. Bioethics. 2025 Jul;39(6):620-629. doi: https://doi.org/10.1111/bioe.13419. Epub 2025 Apr 28. PMID: 40296411; PMCID: PMC12232604.
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Wong CY, Lam RPK, Cheung KS, Kwok WM, Tsang TC, Tsui MSH, Rainer TH. Structured prehospital chest pain assessment and clinical diagnostic score for prehospital identification of ST-segment elevation myocardial infarction before an electrocardiogram. Hong Kong J Emergency Med. 2025 Apr;32:e12070. https://doi.org/10.1002/hkj2.12070
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Zhang X, Cai Y, Sit BHM, Jian RX, Malki Y, Zhang Y, Ong CCY, Li Q, Lam RPK, Rainer TH. Cell-Free Nucleic Acids for Early Diagnosis of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis. Int J Mol Sci. 2025 Feb 12;26(4):1530. doi: https://doi.org/10.3390/ijms26041530. PMID: 40003998; PMCID: PMC11855205.
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Zhang X, Ng TKY, Yang Y, Sit BHM, Jian X, Zhang Y, Li Q, Rainer TH. Early versus delayed anticoagulation treatment for people with non-valvular atrial fibrillation-related acute ischaemic stroke. Cochrane Database Syst Rev. 2025 Jan 8;1(1):CD016045. doi: https://doi.org/10.1002/14651858.CD016045. PMID: 39775525; PMCID: PMC11707822.






